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Gene read counts	Bidirectional read counts	Tfit regions	dREG regions
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Technical details

Sample name	Sample ID	Paper identifier	Protocol	Library prep	Control/Experimental	Wildtype & Untreated	QC score	Replicate
SRZ7349475	1209	Kloetgen2020three	GRO-seq	ligation	control	True	2	1
SRZ7349477	1210	Kloetgen2020three	GRO-seq	ligation	control	True	3	2
SRZ7349479	1211	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349481	1212	Kloetgen2020three	GRO-seq	ligation	experimental	False	3	2
SRZ7349483	1213	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349485	1214	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	2
SRZ7349487	1215	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349489	1216	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	2
SRZ7349491	1217	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349493	1218	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	2
SRZ7349495	1219	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349497	1220	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	2
SRZ7349499	1221	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349501	1222	Kloetgen2020three	GRO-seq	ligation	experimental	False	3	2
SRZ7349503	1223	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349505	1224	Kloetgen2020three	GRO-seq	ligation	experimental	False	3	2
SRZ7349507	1225	Kloetgen2020three	GRO-seq	ligation	experimental	False	3	1
SRZ7349509	1226	Kloetgen2020three	GRO-seq	ligation	experimental	False	4	2
SRZ7349511	1227	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	1
SRZ7349513	1228	Kloetgen2020three	GRO-seq	ligation	experimental	False	2	2

Cellular details

Sample name	Organism	Sample type	Cell type	Clone/Individual	Strain	Genotype	Construct
SRZ7349475	H. sapiens	cell line	CUTLL1
SRZ7349477	H. sapiens	cell line	CUTLL1
SRZ7349479	H. sapiens	cell line	CUTLL1
SRZ7349481	H. sapiens	cell line	CUTLL1
SRZ7349483	H. sapiens	cell line	CUTLL1
SRZ7349485	H. sapiens	cell line	CUTLL1
SRZ7349487	H. sapiens	cell line	CUTLL1
SRZ7349489	H. sapiens	cell line	CUTLL1
SRZ7349491	H. sapiens	cell line	CUTLL1
SRZ7349493	H. sapiens	cell line	CUTLL1
SRZ7349495	H. sapiens	cell line	CUTLL1
SRZ7349497	H. sapiens	cell line	CUTLL1
SRZ7349499	H. sapiens	cell line	CUTLL1
SRZ7349501	H. sapiens	cell line	CUTLL1
SRZ7349503	H. sapiens	cell line	CUTLL1
SRZ7349505	H. sapiens	cell line	CUTLL1
SRZ7349507	H. sapiens	cell line	CUTLL1
SRZ7349509	H. sapiens	cell line	CUTLL1
SRZ7349511	H. sapiens	cell line	CUTLL1
SRZ7349513	H. sapiens	cell line	CUTLL1

Conditions

Sample name	Condition type	Treatment	Start time	End time	Duration
SRZ7349475	vehicle	DMSO	-72 hr	0 hr	3 day
SRZ7349477	vehicle	DMSO	-72 hr	0 hr	3 day
SRZ7349479	treatment	gamma-secretase inhibitor (1 microM)	-72 hr	0 hr	3 day
SRZ7349481	treatment	gamma-secretase inhibitor (1 microM)	-72 hr	0 hr	3 day
SRZ7349483	treatment	gamma-secretase inhibitor (1 microM)	-73 hr	-1 hr	3 day
SRZ7349485	treatment	gamma-secretase inhibitor (1 microM)	-73 hr	-1 hr	3 day
SRZ7349487	treatment	gamma-secretase inhibitor (1 microM)	-74 hr	-2 hr	3 day
SRZ7349489	treatment	gamma-secretase inhibitor (1 microM)	-74 hr	-2 hr	3 day
SRZ7349491	treatment	gamma-secretase inhibitor (1 microM)	-75 hr	-3 hr	3 day
SRZ7349493	treatment	gamma-secretase inhibitor (1 microM)	-75 hr	-3 hr	3 day
SRZ7349495	treatment	gamma-secretase inhibitor (1 microM)	-76 hr	-4 hr	3 day
SRZ7349497	treatment	gamma-secretase inhibitor (1 microM)	-76 hr	-4 hr	3 day
SRZ7349499	treatment	gamma-secretase inhibitor (1 microM)	-77 hr	-5 hr	3 day
SRZ7349501	treatment	gamma-secretase inhibitor (1 microM)	-77 hr	-5 hr	3 day
SRZ7349503	treatment	gamma-secretase inhibitor (1 microM)	-78 hr	-6 hr	3 day
SRZ7349505	treatment	gamma-secretase inhibitor (1 microM)	-78 hr	-6 hr	3 day
SRZ7349507	treatment	gamma-secretase inhibitor (1 microM)	-80 hr	-8 hr	3 day
SRZ7349509	treatment	gamma-secretase inhibitor (1 microM)	-80 hr	-8 hr	3 day
SRZ7349511	treatment	gamma-secretase inhibitor (1 microM)	-82 hr	-10 hr	3 day
SRZ7349513	treatment	gamma-secretase inhibitor (1 microM)	-82 hr	-10 hr	3 day

Sample metrics

Sample name	Raw read length	Trim read depth	Duplication proportion	Proportion reads mapped	Exon/intron ratio	Unique read proportion	Sample QC score	Sample NRO score
SRZ7349475	51	23,421,418	0.61686	0.9622	3.91231	0.42881	2	2
SRZ7349477	51	24,278,139	0.67563	0.9653	4.47723	0.36837	3	2
SRZ7349479	51	16,666,631	0.62565	0.9516	3.44351	0.42845	2	2
SRZ7349481	51	23,639,478	0.68933	0.9649	4.26357	0.35105	3	2
SRZ7349483	51	18,827,900	0.60953	0.9618	3.61132	0.4431	2	2
SRZ7349485	51	20,549,473	0.63535	0.9582	3.57407	0.41422	2	2
SRZ7349487	51	17,551,736	0.63376	0.9597	3.33996	0.43567	2	2
SRZ7349489	51	17,479,238	0.5731	0.9517	2.99286	0.48712	2	1
SRZ7349491	51	15,977,441	0.59437	0.9446	2.9741	0.45712	2	1
SRZ7349493	51	17,712,923	0.64204	0.9445	2.74503	0.43954	2	1
SRZ7349495	51	17,700,930	0.6306	0.9548	3.85261	0.43313	2	2
SRZ7349497	51	20,090,608	0.64327	0.9571	3.79298	0.41624	2	2
SRZ7349499	51	16,018,477	0.59354	0.9442	2.91509	0.46284	2	1
SRZ7349501	51	19,573,146	0.65663	0.9596	3.73061	0.38761	3	2
SRZ7349503	51	17,085,763	0.57755	0.9504	2.98	0.48154	2	1
SRZ7349505	51	16,908,952	0.6734	0.9566	3.44421	0.38566	3	2
SRZ7349507	51	19,010,499	0.66499	0.9608	4.00429	0.37869	3	2
SRZ7349509	51	15,987,983	0.93585	0.9297	2.92857	0.08185	4	1
SRZ7349511	51	17,522,795	0.61958	0.9589	3.35662	0.44594	2	2
SRZ7349513	51	17,378,483	0.62501	0.9595	3.47191	0.44079	2	2

Bidirectionals

Sample name	Tfit total bidirs	Tfit promoter bidirs	Tfit intronic bidirs	Tfit intergenic bidirs	dREG total bidirs	dREG promoter bidirs	dREG intronic bidirs	dREG intergenic bidirs
SRZ7349475	9388	3085	4431	1015	5111	2130	2050	834
SRZ7349477	8004	2405	3837	665	4126	1700	1620	623
SRZ7349479	7440	1577	3923	938	2980	806	1351	611
SRZ7349481	8025	2317	3824	762	3800	1501	1545	583
SRZ7349483	10902	2909	5579	1259	4489	1717	1939	701
SRZ7349485	8490	2378	4238	900	3835	1423	1670	621
SRZ7349487	8789	1957	4659	1129	3867	1161	1854	690
SRZ7349489	8061	2046	4111	1046	4001	1268	1915	712
SRZ7349491	6615	1369	3474	981	3352	920	1677	632
SRZ7349493	6123	1198	3337	889	3245	770	1667	637
SRZ7349495	11365	3199	5658	1347	5289	1986	2283	862
SRZ7349497	11736	3399	5714	1335	5267	2061	2189	845
SRZ7349499	8326	2229	4240	1066	3927	1266	1809	717
SRZ7349501	8335	2618	3856	874	3944	1569	1640	632
SRZ7349503	8244	2245	4160	1054	4115	1358	1939	717
SRZ7349505	7735	1919	3951	855	3336	1116	1514	560
SRZ7349507	8011	2534	3811	809	3998	1635	1628	631
SRZ7349509	497	117	196	77	396	55	139	137
SRZ7349511	8506	2359	4318	931	4105	1552	1809	646
SRZ7349513	9025	2436	4617	1040	4042	1485	1753	669