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Gene read counts	Bidirectional read counts	Tfit regions	dREG regions
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Technical details

Sample name	Sample ID	Paper identifier	Protocol	Library prep	Control/Experimental	Wildtype & Untreated	QC score	Replicate
SRR5150536	963	Horibata2018erpositive	PRO-seq	ligation	control	True	1	1
SRR5150537	964	Horibata2018erpositive	PRO-seq	ligation	control	True	1	2
SRR5150538	965	Horibata2018erpositive	PRO-seq	ligation	control	False	1	1
SRR5150539	966	Horibata2018erpositive	PRO-seq	ligation	control	False	1	2
SRR5150540	967	Horibata2018erpositive	PRO-seq	ligation	control	True	1	1
SRR5150541	968	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150542	969	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150543	970	Horibata2018erpositive	PRO-seq	ligation	control	False	1	1
SRR5150544	971	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150545	972	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150546	973	Horibata2018erpositive	PRO-seq	ligation	control	True	1	1
SRR5150547	974	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150548	975	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150549	976	Horibata2018erpositive	PRO-seq	ligation	control	True	1	2
SRR5150550	977	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	2
SRR5150551	978	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	2
SRR5150552	979	Horibata2018erpositive	PRO-seq	ligation	control	False	1	1
SRR5150553	980	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150554	981	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	1
SRR5150555	982	Horibata2018erpositive	PRO-seq	ligation	control	False	1	2
SRR5150556	983	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	2
SRR5150557	984	Horibata2018erpositive	PRO-seq	ligation	experimental	False	1	2

Cellular details

Sample name	Organism	Sample type	Cell type	Clone/Individual	Strain	Genotype	Construct
SRR5150536	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150537	H. sapiens	cell line	MCF7	Clone C11 (tamoxifen sensitive)
SRR5150538	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150539	H. sapiens	cell line	MCF7	Clone H9 (tamoxifen resistant)
SRR5150540	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150541	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150542	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150543	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150544	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150545	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150546	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150547	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150548	H. sapiens	cell line	MCF7	Clone B7 (tamoxifen sensitive)
SRR5150549	H. sapiens	cell line	MCF7	Clone C11 (tamoxifen sensitive)
SRR5150550	H. sapiens	cell line	MCF7	Clone C11 (tamoxifen sensitive)
SRR5150551	H. sapiens	cell line	MCF7	Clone C11 (tamoxifen sensitive)
SRR5150552	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150553	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150554	H. sapiens	cell line	MCF7	Clone G11 (tamoxifen resistant)
SRR5150555	H. sapiens	cell line	MCF7	Clone H9 (tamoxifen resistant)
SRR5150556	H. sapiens	cell line	MCF7	Clone H9 (tamoxifen resistant)
SRR5150557	H. sapiens	cell line	MCF7	Clone H9 (tamoxifen resistant)

Conditions

Sample name	Condition type	Treatment	Start time	End time	Duration
SRR5150536	no treatment		None	None	None
SRR5150537	no treatment		None	None	None
SRR5150538	no treatment		None	None	None
SRR5150539	no treatment		None	None	None
SRR5150540	vehicle	ethanol	-40 min	0 min	40 min
SRR5150541	treatment	17-beta-estradiol (100 nM)	-40 min	0 min	40 min
SRR5150542	treatment	hydroxytamoxifen (1 microM)	-40 min	0 min	40 min
SRR5150543	vehicle	ethanol	-40 min	0 min	40 min
SRR5150544	treatment	17-beta-estradiol (100 nM)	-40 min	0 min	40 min
SRR5150545	treatment	hydroxytamoxifen (1 microM)	-40 min	0 min	40 min
SRR5150546	no treatment		None	None	None
SRR5150547	treatment	GDNF (10 ng/mL)	-1 hr	0 hr	1 hr
SRR5150548	treatment	GDNF (10 ng/mL)	-24 hr	0 hr	1 day
SRR5150549	no treatment		None	None	None
SRR5150550	treatment	GDNF (10 ng/mL)	-1 hr	0 hr	1 hr
SRR5150551	treatment	GDNF (10 ng/mL)	-24 hr	0 hr	1 day
SRR5150552	no treatment		None	None	None
SRR5150553	treatment	GDNF (10 ng/mL)	-1 hr	0 hr	1 hr
SRR5150554	treatment	GDNF (10 ng/mL)	-24 hr	0 hr	1 day
SRR5150555	no treatment		None	None	None
SRR5150556	treatment	GDNF (10 ng/mL)	-1 hr	0 hr	1 hr
SRR5150557	treatment	GDNF (10 ng/mL)	-24 hr	0 hr	1 day

Sample metrics

Sample name	Raw read length	Trim read depth	Duplication proportion	Proportion reads mapped	Exon/intron ratio	Unique read proportion	Sample QC score	Sample NRO score
SRR5150536	75	33,465,964	0.33996	0.7392	4.32527	0.71052	1	2
SRR5150537	75	25,777,753	0.334	0.7668	4.31714	0.72414	1	2
SRR5150538	75	33,269,097	0.38321	0.7561	4.79389	0.67118	1	2
SRR5150539	75	30,329,431	0.31912	0.8181	3.90067	0.74415	1	2
SRR5150540	75	28,420,804	0.32263	0.8621	4.30526	0.73297	1	2
SRR5150541	75	33,429,432	0.34725	0.86	4.47619	0.71767	1	2
SRR5150542	75	28,383,158	0.36017	0.8598	4.74938	0.69278	1	2
SRR5150543	75	25,150,052	0.34591	0.8437	3.86104	0.70924	1	2
SRR5150544	75	28,245,517	0.336	0.8963	3.81787	0.71991	1	2
SRR5150545	75	33,122,243	0.33745	0.896	3.7107	0.72923	1	2
SRR5150546	76	28,495,092	0.34182	0.9036	4.58455	0.73206	1	2
SRR5150547	76	24,496,451	0.26838	0.9324	3.46382	0.78543	1	2
SRR5150548	76	28,511,525	0.4393	0.9149	5.5483	0.63317	1	3
SRR5150549	76	27,908,917	0.37073	0.911	5.12107	0.69747	1	3
SRR5150550	76	25,633,146	0.38895	0.912	4.88427	0.67432	1	2
SRR5150551	76	27,516,497	0.41544	0.9249	5.31177	0.65277	1	3
SRR5150552	76	27,738,754	0.38856	0.8858	5.03812	0.68079	1	3
SRR5150553	76	29,763,103	0.46005	0.8783	5.60363	0.61565	1	3
SRR5150554	76	26,292,025	0.41954	0.8969	5.51213	0.64108	1	3
SRR5150555	76	30,850,882	0.43538	0.8894	5.28044	0.64095	1	3
SRR5150556	76	23,570,124	0.41062	0.9051	4.9302	0.64187	1	2
SRR5150557	76	29,653,240	0.41206	0.8922	4.78928	0.66176	1	2

Bidirectionals

Sample name	Tfit total bidirs	Tfit promoter bidirs	Tfit intronic bidirs	Tfit intergenic bidirs	dREG total bidirs	dREG promoter bidirs	dREG intronic bidirs	dREG intergenic bidirs
SRR5150536	31685	16820	10484	4954	20934	8642	7613	3909
SRR5150537	29512	16635	9756	3870	18791	8537	6586	3056
SRR5150538	32209	16640	11021	5360	22721	8843	8685	4419
SRR5150539	28859	15885	9518	4247	20286	8365	7632	3637
SRR5150540	30698	14844	11193	5437	23886	9150	9758	4499
SRR5150541	31089	15018	11215	5638	25124	9330	10506	4835
SRR5150542	30416	14659	11216	5294	24030	9612	9792	4410
SRR5150543	30571	13744	11344	6000	23412	9209	9295	4707
SRR5150544	32213	14502	11656	6663	25520	9395	10486	5351
SRR5150545	31317	14821	11019	6182	24870	9177	10145	5260
SRR5150546	31002	17055	9972	4772	21403	8914	8086	3863
SRR5150547	23920	11978	8234	3401	15271	6980	5546	2372
SRR5150548	30593	17267	10045	4452	22096	9825	8322	3882
SRR5150549	31161	16028	10745	5268	23104	9572	9011	4386
SRR5150550	29003	15775	9979	4162	20128	8800	7834	3232
SRR5150551	29758	16800	9824	4314	21730	9838	8111	3741
SRR5150552	31097	16602	10397	4969	21530	8940	8136	3904
SRR5150553	29293	15935	10088	4173	21096	8859	8248	3464
SRR5150554	30286	16601	10268	4521	22098	9709	8392	3912
SRR5150555	31279	16342	10735	5137	23262	9042	9280	4499
SRR5150556	27272	15146	9475	3646	19785	8949	7658	3049
SRR5150557	28812	15817	9728	4339	21715	9301	8277	3927