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Gene read counts	Bidirectional read counts	Tfit regions	dREG regions
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Technical details

Sample name	Sample ID	Paper identifier	Protocol	Library prep	Control/Experimental	Wildtype & Untreated	QC score	Replicate
SRR1105736	51	Allen2014global	GRO-seq	circularization	control	True	4	1
SRR1105737	52	Allen2014global	GRO-seq	circularization	control	True	3	2
SRR1105738	53	Allen2014global	GRO-seq	circularization	experimental	False	4	1
SRR1105739	54	Allen2014global	GRO-seq	circularization	experimental	False	3	2
SRR1105740	55	Allen2014global	GRO-seq	circularization	experimental	False	3	1
SRR1105741	56	Allen2014global	GRO-seq	circularization	experimental	False	2	1
SRR1224573	57	Allen2014global	GRO-seq	circularization	control	True	2	1
SRR1224574	58	Allen2014global	GRO-seq	circularization	experimental	False	4	1

Cellular details

Sample name	Organism	Sample type	Cell type	Clone/Individual	Strain	Genotype	Construct
SRR1105736	H. sapiens	cell line	HCT116
SRR1105737	H. sapiens	cell line	HCT116
SRR1105738	H. sapiens	cell line	HCT116
SRR1105739	H. sapiens	cell line	HCT116
SRR1105740	H. sapiens	cell line	HCT116			p53 -/-
SRR1105741	H. sapiens	cell line	HCT116			p53 -/-
SRR1224573	H. sapiens	cell line	HCT116
SRR1224574	H. sapiens	cell line	HCT116

Conditions

Sample name	Condition type	Treatment	Start time	End time	Duration
SRR1105736	vehicle	DMSO	-1 hr	0 hr	1 hr
SRR1105737	vehicle	DMSO	-1 hr	0 hr	1 hr
SRR1105738	treatment	nutlin-3 (10 microM)	-1 hr	0 hr	1 hr
SRR1105739	treatment	nutlin-3 (10 microM)	-1 hr	0 hr	1 hr
SRR1105740	vehicle	DMSO	-1 hr	0 hr	1 hr
SRR1105741	treatment	nutlin-3 (10 microM)	-1 hr	0 hr	1 hr
SRR1224573	vehicle	DMSO	-30 min	0 min	30 min
SRR1224574	treatment	nutlin-3 (10 microM)	-30 min	0 min	30 min

Sample metrics

Sample name	Raw read length	Trim read depth	Duplication proportion	Proportion reads mapped	Exon/intron ratio	Unique read proportion	Sample QC score	Sample NRO score
SRR1105736	50	54,636,150	0.88664	0.8586	3.71858	0.31967	4	2
SRR1105737	50	136,926,976	0.73196	0.9291	3.53914	0.5584	3	2
SRR1105738	50	161,191,302	0.80579	0.9182	3.4152	0.5891	4	2
SRR1105739	50	148,186,888	0.79063	0.9355	3.38991	0.53761	3	2
SRR1105740	50	179,414,804	0.79917	0.9294	3.66674	0.55552	3	2
SRR1105741	50	159,917,000	0.64267	0.9368	3.6153	0.59871	2	2
SRR1224573	50	191,455,961	0.64257	0.8497	3.9271	0.61777	2	2
SRR1224574	50	164,646,421	0.83592	0.869	2.69469	0.63233	4	1

Bidirectionals

Sample name	Tfit total bidirs	Tfit promoter bidirs	Tfit intronic bidirs	Tfit intergenic bidirs	dREG total bidirs	dREG promoter bidirs	dREG intronic bidirs	dREG intergenic bidirs
SRR1105736	23858	11356	8829	3050	15716	7332	5135	2577
SRR1105737	52361	19357	18993	12800	41738	8972	18235	13084
SRR1105738	46293	16477	17443	11289	39310	8299	17105	12046
SRR1105739	50624	19493	18545	11556	37972	8940	16075	11563
SRR1105740	47151	19425	15456	11633	40888	9124	17213	13056
SRR1105741	53588	21024	17501	14725	52586	9334	23229	18192
SRR1224573	48411	16551	16534	14306	63240	7707	29969	22603
SRR1224574	42457	16172	15586	9660	36878	8535	16153	10793